MyBioSource.com's CFHR5 Antibody (Center) is a Rabbit Polyclonal antibody. This antibody has been shown to work in applications such as: ELISA, Flow Cytometry, Immunohistochemistry, and Western Blot. The CFHR5 Antibody (Center) was generated using CFHR5, and FHR5 as the antigen and it reacts with Human.
Description
CFHR5 is a member of a small complement factor H (CFH)
gene cluster on chromosome 1. Each member of this gene family
contains multiple short consensus repeats (SCRs) typical of
regulators of complement activation. The protein encoded by this
gene has nine SCRs with the first two repeats having heparin
binding properties, a region within repeats 5-7 having heparin
binding and C reactive protein binding properties, and the
C-terminal repeats being similar to a complement component 3 b
(C3b) binding domain. This protein co-localizes with C3, binds C3b
in a dose-dependent manner, and is recruited to tissues damaged by
C-reactive protein. Allelic variations in this gene have been
associated, but not causally linked, with two different forms of
kidney disease: membranoproliferative glomerulonephritis type II
(MPGNII) and hemolytic uraemic syndrome (HUS). [provided by
RefSeq]